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Removing a protein and enzyme pair can improve cancer treatment

 
ACRF
ACRF
September 20, 2016

Cancer researchers at QIMR Berghofer in Brisbane have found that removing a particular enzyme and protein from the immune system significantly reduces the spread of breast cancer and melanoma.

The enzyme and protein are related to adenosine which is an immunosuppressive molecule that promotes the growth and spread of tumours by sending a message to certain immune cells. This inhibits the immune cells’ ability to kill cancer cells.

The research team at QIMR Berghofer set out to find the best way to stop adenosine from promoting the growth and spread of cancers.

Researcher Arabella Young said they tested this by inhibiting the enzyme that makes adenosine (CD73) and the protein that receives its messages (the A2A receptor) separately and in combination.

“During our laboratory experiments, targeting the enzyme CD73 and the A2A receptor separately slowed the growth and spread of breast cancer and melanoma,” Ms Young said.

“But when we removed the function of both at the same time, it had a more powerful effect, inhibiting the growth and significantly reducing the spread of the cancers.

“In some of our experiments, removing both CD73 and the A2A receptor eliminated the melanomas altogether.”

Implications for cancer treatment

A treatment targeting the A2A receptor is currently in clinical trials. Study leader, Professor Mark Smyth said the Institute’s collaborators at MedImmune had developed another immunotherapy treatment to block CD73 in solid tumours, which is also in clinical trials.

“Up until now, it was believed that targeting each one individually may have the same effect as targeting the two together, but our results have shown otherwise.”

“Removing the enzyme CD73 stops adenosine from being produced and inhibiting the A2A receptor stops adenosine’s message from getting through,” Professor Smyth said.

“This is the first time that anyone looked at the effect of targeting CD73 and the A2A receptor together.”

“Our findings suggest that targeting both would lead to better results for patients.

“We hope that these findings will in future lead to better treatments for a number of cancers, particularly those with high levels of CD73 and adenosine within the tumour, including triple negative breast cancer, high-grade serous ovarian cancer and melanoma.”

The study was led by QIMR Berghofer Medical Research Institute in collaboration with MedImmune. It has been published in the journal Cancer Cell.

The original news article was published on the QIMR Berghof website.

The Australian Cancer Research Foundation has supported cancer research at QIMR Berghofer by providing three grants, totalling AUD$ 6.65 M, for the purchase of cutting edge cancer research equipment and technology.

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